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pentobarbital will minimize the extent or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Pitolisant exposure is lessened by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will lessen the extent or influence of flurbiprofen by influencing hepatic enzyme CYP2C9/ten